FDA Approves Drug Combo to Treat BRAF V600+ Anaplastic Thyroid Cancer
May 4th 2018The FDA has approved the use of the combination of the BRAF-inhibitor dabrafenib (Tafinlar) and MEK-inhibitor trametinib (Mekinist) for the treatment of patients with unresectable or metastatic BRAFV600E–positive anaplastic thyroid cancer (ATC).
What the Frontline Osimertinib Approval Means for Treatment of EGFR+ NSCLC
May 3rd 2018Helena A. Yu, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center, explains the implications of the approval of osimertinib as the frontline standard of care for patients with EGFR-mutant non–small cell lung cancer.
FDA Approves Tisaganlecleucel for Relapsed/Refractory Large B-Cell Lymphoma
May 2nd 2018The FDA has approved the chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel (Kymriah) for use in adult patients with relapsed/refractory large B-cell lymphoma—including diffuse large B-cell lymphoma (DLBCL), high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma—after 2 or more lines of systemic therapy.
FDA Approves Adjuvant Treatment Combination for Patients With BRAF+ Melanoma
May 1st 2018The FDA has approved the combined use of dabrafenib (Tafinlar) and trametinib (Mekinist) in the adjuvant setting for patients with BRAF V600E– or V600K–positive stage III melanoma following complete resection.
FDA Grants Priority Review to Cemiplimab for Treatment of Metastatic CSCC
May 1st 2018The FDA has granted a priority review to a biologics license application (BLA) for cemiplimab, a PD-1 inhibitor, for use in the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or patients with locally advanced CSCC who are not eligible for surgery.
FDA Grants Priority Review for Frontline Pembrolizumab Combo in NSCLC
April 30th 2018The FDA has granted a priority review for frontline use of the PD-1 inhibitor pembrolizumab (Keytruda) in combination with standard chemotherapy for patients with metastatic nonsquamous non–small cell lung cancer.
BLU-667 Shows Clinical Benefit in Advanced, RET-Altered Solid Tumors
April 20th 2018BLU-667 appeared to be well-tolerated and had broad clinical benefit among patients with advanced, RET-altered solid tumors who progressed on prior therapies, according to study findings from a phase I clinical trial presented at the AACR Annual Meeting 2018.
NCCN Guidelines on Breast Cancer Impact Clinical Applications of Radiation Therapy
April 20th 2018The National Comprehensive Cancer Network (NCCN) guidelines on breast cancer now allow physicians to pinpoint the women who are most likely to benefit from post-mastectomy radiation using the latest targeted testing techniques.
FDA Grants Nivolumab Priority Review for SCLC Treatment
April 19th 2018The FDA has granted priority review to a supplemental biologics license application for nivolumab (Opdivo) to be used to treat patients with small cell lung cancer who have already had two or more lines of therapy, and whose disease has continued to progress.