Frontline Obinutuzumab Granted FDA Approval for Advanced Follicular Lymphoma
November 16th 2017The FDA has approved obinutuzumab (Gazyva) in combination with chemotherapy, followed by obinutuzumab alone, for the first-line treatment of patients with advanced follicular lymphoma, according to Genentech, the manufacturer of the therapy.
Combination Approved for Metastatic or Advanced Breast Cancer Treatment
November 15th 2017The FDA has approved fulvestrant (Faslodex) for use in combination with the CDK4/6 inhibitor abemaciclib (Verzenio) to treat patients with HR+/HER2- advanced or metastatic breast cancer who have progressed after endocrine therapy.
Neoadjuvant Nivolumab Plus Ipilimumab Is Effective, But Toxic in Melanoma
November 14th 2017Neoadjuvant treatment with the combination of nivolumab (Opdivo) and ipilimumab (Yervoy) demonstrated almost a tripling in objective response rate (ORR) compared with the PD-1 inhibitor alone but at the cost of significant added grade 3 adverse events (AEs) for patients with high-risk resectable melanoma, according to a small study presented at the 2017 SITC Annual Meeting.
Disparity in US Breast Cancer Mortality
November 14th 2017Breast cancer, the most common cancer diagnosed in women in the United States, is the second leading cause of cancer death among women after lung cancer. To track trends in disease incidence, mortality, and survival the American Cancer Society (ACS) analyzes data every 2 years.
FDA Approves Aprepitant to Treat Chemotherapy-Induced Nausea and Vomiting
November 10th 2017Aprepitant (Cinvanti), an injectable emulsion, is the second agent in just over two weeks to be approved by the Food and Drug Administration (FDA) for the treatment of chemotherapy-induced nausea/vomiting (CINV).
Brentuximab Vedotin Granted FDA Approval for CTCL
November 10th 2017The FDA has approved brentuximab vedotin (Adcetris) as a treatment for patients with cutaneous T-cell lymphoma (CTCL) who have received prior systemic therapy, according to Seattle Genetics, which codevelops the antibody-drug conjugate with Takeda.
Letermovir Granted FDA Approval for CMV Prophylaxis After Transplant
November 9th 2017The FDA has approved letermovir (Prevymis) to prevent cytomegalovirus (CMV) infection in adult CMV-seropositive patients treated with an allogeneic hematopoietic stem cell transplant (HSCT), based on a significant reduction in CMV infection rates in a phase III study.
Chicago Cancer Institutions Collaborate to Improve Care
November 8th 2017Over the last four years, the Coleman Supportive Oncology Collaborative (CSOC), a group of professionals from academic, community and public cancer centers and hospice providers, has been developinging tools and resources to address gaps in cancer care in the Chicago area.
Significant Rate of Febrile Neutropenia Seen in CDK 4/6 Inhibitor Based Regimens
November 6th 2017Cyclin D–dependent kinase (CDK) 4/6 inhibitors have proven to be effective treatment in patients with hormone receptor-positive HER2-negative metastatic breast cancer. But, much like many cancer therapies, there are challenges when it comes to toxicity.
Many Tanning Salons Not Compliant With State Laws, Study Finds
November 3rd 2017Overall, 159 of the 427 tanning salons were out of compliance, and most of them were in rural locations and southern regions of the United States. Additionally, this was more common in independently owned salons, in states with younger age groups being regulated and in states with more than one tanning regulation.
Expert Discusses the Present and Future of Genetic Testing in Breast Cancer
November 2nd 2017Laura J. van’t Veer, PhD, discussed determining more accurate methods of treatment for patients with early- and late-state breast cancer based on advances in genetic testing, specifically the 70-gene prognostic signature.
Acalabrutinib Granted FDA Approval for Mantle Cell Lymphoma Treatment
October 31st 2017The FDA has granted an accelerated approval to acalabrutinib (Calquence) as a treatment for adult patients with mantle cell lymphoma (MCL) following at least 1 prior therapy, based on objective response rates (ORR) in a single-arm trial.
IV Rolapitant Approved for Delayed CINV Treatment
October 26th 2017The FDA has approved intravenous (IV) rolapitant (Varubi) for use in combination with other antiemetic agents to treat delayed chemotherapy-induced nausea and vomiting (CINV) in adults, according to TESARO, the manufacturer of the agent.
Dabrafenib Plus Trametinib Granted Breakthrough Therapy Designation for Melanoma
October 24th 2017The FDA has awarded the combination of dabrafenib (Tafinlar) and trametinib (Mekinist) a breakthrough therapy designation for the adjuvant treatment of patients with stage III melanoma with a BRAF V600 mutation following complete resection.