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Belzutifan improved progression-free survival and objective response rate compared to everolimus in previously treated advanced renal cell carcinoma. 

Belzutifan Has Durable PFS, ORR in Previously Treated Advanced Clear Cell RCC

Adjuvant durvalumab failed to improve disease-free survival in resected EGFR- or ALK-negative non-small cell lung cancer. 

Postsurgical Durvalumab Does Not Boost DFS in Lung Cancer

Michael Lai, ARNP, explained the mechanism of action of PARP inhibitors for the treatment of patients with prostate cancer.

Understanding the Mechanism of Action Behind PARP Inhibitors for Prostate Cancer

The Immune Effector Cell Encephalopathy score and keeping a close eye on patients’ symptoms are critical when monitoring for potential ICANS during lymphoma treatment.

Tools to Monitor for ICANS During Lymphoma Treatment With Bispecific Antibodies, CAR T-Cell Therapy

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Caroline Seymour joined MJH Life Sciences in 2018 and has expertise in video production and print/digital publication. Email: cseymour@onclive.com​

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A group of oncology advanced practice providers discussed the use of BCMA-targeted bispecific antibodies for patients with relapsed/refractory multiple myeloma. 

BCMA-Targeted Bispecific Antibodies Are ‘Encouraging’ for Some With Myeloma 

Both community and academic nurses must know what to expect and how to react to adverse events from bispecific antibody treatment in myeloma; however, Donna Catamero, ANP-BC, OCN, CCRC, notes this can be predictable for providers.

AE Profile of Bispecific Antibodies Can Be Predictable in Myeloma Management

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Between the Lines: Recent Updates in Treatment and Strategies for Managing Adverse Events in Multiple Myeloma

Managing toxicities of BCMA_targeting Bispecfics

Video content above is prompted by the following:

What are some other toxicities observed with B-cell maturation antigen–targeting bispecifics? How are they managed in your practice?

Infections, neurotoxicity, hematological toxicities

Larysa Sanchez, MD; and Samantha Shenoy, MSN, NP, discuss the management of adverse events with bispecific antibodies like GPRC5D and talquetamab while providing guidance on optimizing treatment outcomes and supportive care, as well as offering advice for managing toxicities and future perspectives on relapsed/refractory multiple myeloma.

Medical experts  give an overview of relapsed/refractory multiple myeloma, focusing on diagnosis and current management strategies

Overview of Relapsed/Refractory Multiple Myeloma: Diagnosis, Treatment Options, Unmeet Needs

Experts give an overview of long-term follow-up efficacy data from the MonumenTAL-1 study.

MonumenTAL-1: Long Term Follow up Efficacy

Experts give an overview of safety data from the MonumenTAL-1 study.

MonumenTAL-1: Safety and AEs

Experts address the unique challenges in managing adverse events associated with GPRC5D therapies compared to other cancer treatments, while Samantha will discuss strategies for preparing and educating patients undergoing GPRC5D therapy.

Managing GPRC5D Therapy: Unique AE Challenges and Patient Preparation

Experts explain the administration of step-up and treatment doses for GPRC5D at your institution, including whether they are given in clinic or in the community, and will discuss how patients are monitored for cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome during the step-up phase.

Administering GPRC5D therapy: Dosing and Monitoring for CRS & ICANS 

Experts explore additional toxicities observed with B-cell maturation antigen–targeting bispecifics, such as infections, neurotoxicity, and hematological issues, and discuss how these are managed in practice.

Managing toxicities of BCMA_targeting Bispecfics

EP: 1.Overview of Relapsed/Refractory Multiple Myeloma: Diagnosis, Treatment Options, Unmeet Needs

EP: 2.MonumenTAL-1: Long Term Follow up Efficacy

EP: 3.MonumenTAL-1: Safety and AEs

EP: 4.Managing GPRC5D Therapy: Unique AE Challenges and Patient Preparation

EP: 5.Administering GPRC5D therapy: Dosing and Monitoring for CRS & ICANS

EP: 6.Managing toxicities of BCMA_targeting Bispecfics

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