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Adding E-602 to cemiplimab demonstrated anti-tumor effects in patients PD-L1–resistant solid cancers. 

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Docetaxel was associated with lower rates of peripheral neuropathy compared with paclitaxel for Black patients with breast cancer. 

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PARP inhibitors have changed the way we think about [managing] ovarian cancer,” Whitney Goldsberry, MD, said 

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The FDA accepted a supplemental new drug application to darolutamide plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer. 

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Between the Lines: Recent Updates in Treatment and Strategies for Managing Adverse Events in Multiple Myeloma

Management of Oral Toxcities associated with GPRC5D Bispecifics Nail

Video content above is prompted by the following:

What are some adverse events (AEs) observed with talquetamab and how are these managed?

Please discuss management of oral toxicities.

Please discuss management of skin and nail AEs.

Larysa Sanchez, MD; and Samantha Shenoy, MSN, NP, discuss the management of adverse events with bispecific antibodies like GPRC5D and talquetamab while providing guidance on optimizing treatment outcomes and supportive care, as well as offering advice for managing toxicities and future perspectives on relapsed/refractory multiple myeloma.

Medical experts  give an overview of relapsed/refractory multiple myeloma, focusing on diagnosis and current management strategies

Overview of Relapsed/Refractory Multiple Myeloma: Diagnosis, Treatment Options, Unmeet Needs

Experts give an overview of long-term follow-up efficacy data from the MonumenTAL-1 study.

MonumenTAL-1: Long Term Follow up Efficacy

Experts give an overview of safety data from the MonumenTAL-1 study.

MonumenTAL-1: Safety and AEs

Experts address the unique challenges in managing adverse events associated with GPRC5D therapies compared to other cancer treatments, while Samantha will discuss strategies for preparing and educating patients undergoing GPRC5D therapy.

Managing GPRC5D Therapy: Unique AE Challenges and Patient Preparation

Experts explain the administration of step-up and treatment doses for GPRC5D at your institution, including whether they are given in clinic or in the community, and will discuss how patients are monitored for cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome during the step-up phase.

Administering GPRC5D therapy: Dosing and Monitoring for CRS & ICANS 

Experts explore additional toxicities observed with B-cell maturation antigen–targeting bispecifics, such as infections, neurotoxicity, and hematological issues, and discuss how these are managed in practice.

Managing toxicities of BCMA_targeting Bispecfics

Experts discuss the adverse events observed with talquetamab, including oral toxicities and skin and nail issues, and how these are managed.

Experts discuss prophylactic measures for managing potential adverse events associated with talquetamab and other bispecifics, while all faculty will offer advice for health care providers involved in the care of patients receiving talquetamab.

Prophylactic Strategies and Advice for Managing AEs in  Bispecific Therapies 

Experts provide advice to patients and caregivers on managing oral and skin toxicities.

Management of Skin and Nail AEs: Advice to Patients and Caregivers

Experts provide advice for patients and caregivers with relapsed/refractory multiple myeloma considering talquetamab or another bispecific, while all faculty will discuss unmet needs and future perspectives in the treatment of relapsed/refractory multiple myeloma.

Management of Oral Toxcities associated with GPRC5D Bispecifics Nail

EP: 1.Overview of Relapsed/Refractory Multiple Myeloma: Diagnosis, Treatment Options, Unmeet Needs

EP: 2.MonumenTAL-1: Long Term Follow up Efficacy

EP: 3.MonumenTAL-1: Safety and AEs

EP: 4.Managing GPRC5D Therapy: Unique AE Challenges and Patient Preparation

EP: 5.Administering GPRC5D therapy: Dosing and Monitoring for CRS & ICANS

EP: 6.Managing toxicities of BCMA_targeting Bispecfics

EP: 7.Management of Oral Toxcities associated with GPRC5D Bispecifics Nail

EP: 8.Prophylactic Strategies and Advice for Managing AEs in Bispecific Therapies

EP: 9.Management of Skin and Nail AEs: Advice to Patients and Caregivers

EP: 10.Unmet Needs and Future Perspectives on the treatment of R/R MM

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