FDA Grants Priority Review to Frontline Pembro to Treat Recurrent, Metastatic HNSCC
February 11th 2019The FDA granted a priority review to the supplemental biologics license application for pembrolizumab (Keytruda) for the first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).
Luspatercept Reduces Blood Transfusion Dependence in Lower-Risk MDS Anemia
December 12th 2018Treatment with luspatercept significantly reduced the need for frequent red blood cell transfusions in nearly 53% of patients with anemia associated with low- to intermediate-risk myelodysplastic syndrome (MDS), according to results from the phase III Medalist trial presented at the 2018 ASH Annual Meeting.
Beat AML Trial Proves Feasibility of Rapid Treatment Assignment Following Diagnosis
December 8th 2018Hematologists may have the ability to determine acute myeloid leukemia (AML) subtype based on genetic analysis of blood samples in 7 days or less, a process that could soon be an integral part of diagnosing and treating this patient population, according to Amy Burd, PhD.
First HCT Following CAR T-Cell Therapy Reduces Risk for ALL Relapse
December 8th 2018Receiving a stem cell transplant for the first time following CD19 CAR T-cell therapy induced a reduction in the risk for acute lymphoblastic leukemia (ALL) recurrence, according to a retrospective analysis of the phase I/II PLAT-02 study.1
FDA Grants Atezolizumab Combo Priority Review for First-Line Use in SCLC
December 5th 2018The FDA has granted a priority review designation to atezolizumab (Tecentriq) for use in combination with carboplatin and etoposide for the first-line treatment of patients with extensive-stage small cell lung cancer (ES-SCLC).
Tivozanib Improves Progression-Free Survival in Renal Cell Carcinoma
November 24th 2018Patients with renal cell carcinoma (RCC) who were treated with tivozanib (Fotivda) experienced a 26% reduction in the risk of progression or death compared with sorafenib (Nexavar), according to results from the phase 3 TIVO-3 trial.
FDA Grants Priority Review to Atezolizumab Combination for Metastatic TNBC Subset
November 13th 2018The Food and Drug Administration (FDA) granted a priority review to atezolizumab (Tecentriq) in combination with nab-paclitaxel (Abraxane) for frontline use in patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose disease expresses the PD-L1 protein.
FDA Grants Priority Review to Ruxolitinib for Acute GVHD
October 27th 2018The Food and Drug Administration has granted a priority review to the supplemental new drug application for ruxolitinib (Jakafi) to treat patients with acute graft-versus-host-disease (GVHD) who have had an inadequate response to corticosteroids.
Adding Durvalumab to Chemoradiation Improves OS in Unresectable Stage III NSCLC
October 4th 2018Durvalumab (Imfinzi) induced a clinically meaningful improvement in overall survival (OS) compared with placebo in patients with stage III, unresectable non–small cell lung cancer (NSCLC) who have not progressed following chemoradiotherapy.
Brigatinib Bests Standard of Care to Improve PFS in Advanced NSCLC
October 2nd 2018Brigatinib (Alunbrig) reduced the risk of disease progression or death by more than 50% compared to crizotinib (Xalkori) in adult patients with ALK-positive, locally advanced or metastatic non–small cell lung cancer (NSCLC) who had not received a prior ALK inhibitor.
Atezolizumab Improves Survival in Extensive-Stage Small Cell Lung Cancer
September 28th 2018In combination with the standard front-line chemotherapy regimen of carboplatin and etoposide, the addition of atezolizumab (Tecentriq) significantly prolonged survival in patients with extensive-stage small cell lung cancer (ES-SCLC).
FDA Grants Priority Review to Pembrolizumab for PD-L1-High Subgroup of NSCLC
September 12th 2018The Food and Drug Administration (FDA) granted priority review to pembrolizumab (Keytruda) monotherapy for the first-line treatment of patients with locally advanced or metastatic nonsquamous or squamous non-small cell lung cancer (NSCLC) whose tumors express PD-L1 without EGFR or ALK genomic tumor aberrations.
FDA Grants Priority Review to Pembrolizumab for Advanced Merkel Cell Carcinoma
September 4th 2018The Food and Drug Administration (FDA) granted priority review to pembrolizumab (Keytruda) for the treatment of adults and children with recurrent locally advanced or metastatic Merkel cell carcinoma, a rare skin cancer.
Physicians With Personal Cancer Experience May Recommend Ovarian Cancer Screening Despite Guidelines
August 29th 2018A recent survey of physicians revealed that 17% of doctors with personal experience with cancer were more likely than those without to act against established guidelines to recommend that low-risk women receive ovarian cancer screening.
Pediatric Guidelines for CAR T-Cell Therapy Help Nurses Recognize AEs Earlier
August 23rd 2018A year after the first CAR T-cell therapy was approved to treat pediatric patients with relapsed and/or refractory CD19-positive acute lymphoblastic leukemia (ALL), researchers have issued guidelines to help healthcare professionals recognize and treat the associated adverse events (AEs) from this treatment.