New Drug Approvals Expand cGVHD Treatment Beyond Steroids, But Real-World Data Still Needed
October 30th 2021Ruxolitinib and belumosudil represent FDA-approved treatment options to manage cGVHD, however, real world data will determine best practices for treatment and future research directions within the space.
EC-18 Improves Length and Frequency of Chemoradiation-Induced Oral Mucositis in Head and Neck Cancer
October 29th 2021The small molecule oral immunomodulator EC-18 reduced the duration and incidence of severe oral mucositis in patients with head and neck cancer undergoing concurrent chemoradiation.
UGN-102 Induces Durable Responses in Patients with Low-Grade Intermediate-Risk NMIBC
October 24th 2021Approximately 73% of patients with NMIBC who experienced a complete response after non-surgical primary chemoablation using mitomycin-containing reverse thermal gel UGN-102 remained disease free at 9 months.
New Clinical Trial Will Assess Novel ADC in Drug Resistant HER2+ Breast Cancer
October 23rd 2021The recently launched phase 2 ACE-Breast03 seeks to appraise the efficacy and safety of the novel antibody-drug conjugate, ARX788, in patients with metastatic HER2-positive breast cancer whose disease is resistant to previous targeted therapies.
Inguinofemoral Radiotherapy May Be Potential Alternative To Lymphadenectomy In Select Vulvar Cancer
October 21st 2021Inguinofemoral radiotherapy may be a safe alternative for patients with vulvar cancer and sentinel node micrometastases who might otherwise face the morbidity of a lymphadenectomy.
Sintilimab Plus Chemotherapy Induces Superior Survival in EGFR-Mutated Nonsquamous NSCLC
October 19th 2021Sintilimab, a bevacizumab biosimilar injection, met the primary end point of the phase 3 ORIENT-31 trial by significantly increasing progression-free survival in patients with EGFR-mutated, nonsquamous, non–small cell lung cancer.
Axitinib/Pembrolizumab Combination Improves Survival in Metastatic RCC, But Only Marginally
October 17th 2021A real-world survival analysis showed that patients with metastatic RCC treated with axitinib plus pembrolizumab did not experience significantly improved survival outcomes compared with patients treated with ipilimumab plus nivolumab.
FDA Type A Meeting Steers Oral Paclitaxel/Encequidar Research in New Direction
October 16th 2021After a Type A meeting with the FDA regarding oral paclitaxel/encequidar in metastatic breast cancer, Athenex, Inc. has announced that they will be deploying their resources to other avenues of research.