Durvalumab Plus Neoadjuvant Chemo Improves CR in Gastric/GEJ Cancers
January 19th 2024Patients with resectable gastric and GEJ cancers, regardless of region, experienced an improved pathologic complete response to treatment with durvalumab plus neoadjuvant FLOT compared with chemotherapy alone.
Adding Nivolumab to Chemo Increases OS, PFS in Previously Untreated Advanced GI Cancers
January 19th 2024Overall survival and progression-free survival improves with nivolumab plus chemotherapy compared with chemotherapy alone in the overall population and in patients with a PD-L1 CPS of 5 or greater.
NX-5948 Gets FDA Fast Track Designation for Relapsed/Refractory CLL/SLL
January 18th 2024A fast track designation has been granted by the FDA to the novel BTK degrader, NX-5948, for adults with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma who were treated with at least two lines of therapy, including a BTK inhibitor and a BCL2 inhibitor.
Newly Diagnosed Ph+ CML Derives MMR Benefits With Asciminib vs SOC TKIs
January 17th 2024Treatment with asciminib for newly diagnosed, Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase induced statistically significant and clinically meaningful major molecular response benefits compared with standard-of-care TKIs.
HER2+ Breast Cancer May Respond to Neoadjuvant HER2 Blockade Plus Polychemotherapy
January 16th 2024Treatment with pegylated liposomal doxorubicin and cyclophosphamide in the neoadjuvant setting, followed by a taxane, in addition to trastuzumab and pertuzumab, resulted in antitumor activity in patients with HER2-positive breast cancer.
Informing Patients With Cancer on Available Resources Can Address Financial Toxicity
January 15th 2024Speaking with patients with cancer about financial toxicity, including available resources to help them pay for treatment and other necessities, can become a collaborative effort within an institution.
ADC Gets FDA Fast Track Designation for Platinum-Resistant Recurrent Ovarian Cancer
January 15th 2024RC88, a mesothelin-targeting antibody-drug conjugate, was granted a fast track designation from the FDA for the treatment of platinum-resistant recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.
TAR-200 Receives Breakthrough Therapy Designation From FDA for BCG-Unresponsive High-Risk NMIBC
January 14th 2024A breakthrough therapy designation has been granted by the FDA to TAR-200 for the treatment of Bacillus Calmette-Guérin–unresponsive, high-risk non–muscle invasive bladder cancer who are not eligible for or opted not to receive radical cystectomy.
Pathologic Responses Result From Neoadjuvant SBRT Plus Cemiplimab in Resectable HCC
January 11th 2024Three patients with resectable hepatocellular carcinoma experienced significant tumor necrosis greater than 70% after neoadjuvant treatment with low-dose stereotactic body radiation therapy and cemiplimab-rwlc, in addition to adjuvant cemiplimab.
LUMINANCE Study Supports Durvalumab Plus Platinum/Etoposide in Frontline Treatment of ES-SCLC
January 10th 2024Findings from the phase 3b LUMINANCE study aligned with safety and efficacy outcomes from the phase 3 CASPIAN trial, both of which focused on the administration of 5 or more cycles of induction platinum/etoposide alongside durvalumab for the treatment of patients with extensive-stage small cell lung cancer.
Tisotumab Vedotin sBLA Granted Priority Review by FDA for Recurrent/Metastatic Cervical Cancer
January 10th 2024A supplemental biologics license application has been granted priority review by the FDA, which seeks a full approval of tisotumab vedotin for patients with recurrent or metastatic cervical cancer that progressed on or following frontline therapy.
Lenvatinib-Pembrolizumab Combo May Not Improve Survival vs. Docetaxel in Stage IV NSCLC
January 9th 2024A survival advantage via treatment with lenvatinib plus pembrolizumab was not seen when compared with docetaxel for advanced-stage non–small cell lung cancer whose disease progressed after previous exposure to a PD-L1 inhibitor and platinum-based chemotherapy.
Tremelimumab/Durvalumab Plus Chemo Improves Survival in Metastatic NSCLC
January 8th 2024Adding a limited course of tremelimumab to frontline durvalumab and chemotherapy may provide patients with previously untreated metastatic non-small cell lung cancer a sustained overall survival benefit compared with chemotherapy alone.