Cancer Pain Management: Expert Talks Barriers, Management Strategies
March 17th 2020In the midst of the current opioid epidemic, pain management is taking center stage in many healthcare settings, and oncology is no different. It is crucial that patients have their pain – both acute and chronic – managed, while avoiding the potential of drug misuse. Add in barriers to care and other roadblocks, and things become even trickier.
Immunotherapy in SCLC: Results Are Promising, But Biomarkers Are Needed
March 16th 2020After nearly 4 decades of stagnation, the advent of immunotherapy has transformed the frontline treatment paradigm for patients with extensive-stage small cell lung cancer (ES-SCLC). However, biomarkers are needed to better inform which patients are most likely to respond to checkpoint inhibitors, said Jason Niu, MD, PhD.
HCC Treatment Continues to Improve, But Biomarkers Are Still Needed
March 14th 2020A flood of targeted therapy and immunotherapy options to both the first- and second-line settings of hepatocellular carcinoma (HCC) has had significant implications on the treatment of patients in this space and will likely create challenges regarding sequencing, said Richard S. Finn, MD.
FDA Grants Dual Immunotherapy Regimen a Fast Track Designation for Cervical Cancer
March 13th 2020The FDA has granted a Fast Track designation to the combination of the PD-1 inhibitor balstilimab and the CTLA-inhibitor zalifrelimab for the treatment of patients with relapsed or refractory metastatic cervical cancer.
FDA Approves Cytology Test to Improve Prevention of Cervical Cancer
March 11th 2020The FDA has approved the CINtec® PLUS Cytology test as the first biomarker-based triage test for women whose primary cervical cancer screening results are positive for the human papillomavirus (HPV) using the cobas® 4800 HPV Test, according to Roche (Genentech), the manufacturer of the test.
Umbralisib Granted Orphan Drug Status for Follicular Lymphoma
March 7th 2020The FDA has granted an orphan drug designation to umbralisib for the treatment of patients with follicular lymphoma, according to TG Therapeutics, Inc, the developer of the dual inhibitor of PI3K-delta and CK1-epsilon.
Individualized Treatment Is Key for mCRC
March 5th 2020Key elements that should inform treatment decisions for patients with metastatic colorectal cancer (mCRC) include molecular profiling, tumor sidedness, and microsatellite instability–high (MSI-H)/mismatch repair deficient (dMMR) status, according to Michael J. Overman, MD.
Antidepressant May Improve Prostate Cancer Outcomes
March 4th 2020The antidepressant phenelzine showed antitumor activity in patients with biochemical recurrent castrate-sensitive prostate cancer, according to a pilot study conducted by researchers at the University of Southern California (USC).
FDA Approves Isatuximab-irfc for Previously Treated Myeloma
March 3rd 2020The Food and Drug Administration (FDA) approved isatuximab-irfc (Sarclisa) plus pomalidomide and dexamethasone for the treatment of adults with multiple myeloma who had 2 or more prior therapies, including lenalidomide and a proteasome inhibitor.
FDA Grants Priority Review to Tafasitamab/Lenalidomide Combination for DLBCL
March 2nd 2020The FDA granted priority review to a biologics license application for tafasitamab in combination with lenalidomide for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma.
Laparoscopic Power Morcellators for Gynecologic Surgery: FDA Releases Safety Statement
March 2nd 2020In an effort to make the use of laparoscopic power morcellators (LPMs) a safer and more effective choice in gynecologic surgeries, the FDA has released a statement that it will be putting a handful of strategies and recommendations in place
More Work Needed to Determine Best Treatment for High-Risk Myeloma
February 29th 2020Autologous stem cell transplantation continues to have a significant role for patients with high-risk myeloma; however, research efforts continue to focus on novel induction, consolidation, and maintenance regimens, as well as the use of tandem transplant, explained Andrew Branagan, MD.
FDA ODAC Votes on Safety and Efficacy of Ramucirumab Plus Erlotinib for EGFR+ NSCLC
February 27th 2020The FDA Oncologic Drugs Advisory Committee voted 6 to 5 that ramucirumab plus erlotinib demonstrated a favorable benefit and risk profile for patients with untreated metastatic EGFR-positive non-small cell lung cancer.