Addressing Fear and Dread of Prostate Cancer Screening
September 28th 2018To determine what Americans know—and think they know—about prostate cancer, the PCF surveyed more than 2000 adults in the United States and uncovered some misperceptions that might prevent men who are at risk from accessing screening.
FDA Approves Dacomitinib for First-Line Treatment in EGFR+ NSCLC
September 28th 2018The FDA has approved the pan-human EGFR tyrosine kinase inhibitor (TKI) dacomitinib (Vizimpro) for treatment of patients with metastatic non–small cell lung cancer (NSCLC) with EGFR exon 19 deletion or exon 21 L858R substitution mutations in the frontline setting.
Atezolizumab Improves Survival in Extensive-Stage Small Cell Lung Cancer
September 28th 2018In combination with the standard front-line chemotherapy regimen of carboplatin and etoposide, the addition of atezolizumab (Tecentriq) significantly prolonged survival in patients with extensive-stage small cell lung cancer (ES-SCLC).
Regorafenib Sustains OS Benefit in RESORCE Trial Update
September 26th 2018Regorafenib (Stivarga) maintained a prolonged overall survival (OS) benefit as second-line therapy for patients with advanced hepatocellular carcinoma (HCC) in a 2-year updated analysis of key findings from the pivotal RESORCE trial.
Published Results Confirm Regorafenib Safety, Efficacy in mCRC
September 25th 2018Safety and efficacy findings for regorafenib (Stivarga) in patients with previously treated metastatic colorectal cancer (mCRC) were consistent with previous phase III results, according to findings from the phase IIIb CONSIGN trial.
Asymptomatic, Young Patients With MCL May Avoid Active Treatment
September 25th 2018Frontline therapy may be able to be avoided in asymptomatic, young, fit patients with mantle cell lymphoma (MCL), explained Simon Rule, MD, PhD, in a presentation during the 2018 SOHO Annual Meeting. Active treatment in this patient population could potentially lead to unnecessary toxicities, he added.
MONALEESA-3 Data Highlight Ribociclib as Standard in HR+ Breast Cancer
September 24th 2018Findings from the MONALEESA-3 trial dispelled the theory that a CDK4/6 inhibitor had to be reserved following recurrence on hormone therapy in postmenopausal patients with hormone receptor (HR)-positive, HER2-negative breast cancer, explained Dennis J. Slamon, MD, PhD.
Tobacco Control Expert Lauds FDA Crackdown on E-cigarette Sales to Youths
September 22nd 2018The Food and Drug Administration (FDA)’s recent crackdown on retailers and manufacturers who are marketing and selling e-cigarettes and e-cig products to youths was a step forward in the fight to prevent smoking in young people, says Linda Sarna, PhD, RN, FAAN.
Carfilzomib-Based Regimens Deemed Safe in Multiple Myeloma
September 21st 2018Two trials have shown that carfilzomib (Kyprolis)-based regimens appeared to be a safe and effective treatments for all patients with multiple myeloma, according to updated data from the ASPIRE and ENDEAVOR trials presented at the 2018 SOHO Annual Meeting.
Avelumab/Axitinib Combo Benefits Treatment-Naive Patients with RCC
September 20th 2018Combining the PD-L1 inhibitor avelumab (Bavencio) with the VEGF inhibitor axitinib (Inlyta) significantly improved progression-free survival (PFS) compared with sunitinib (Sutent) in treatment-naïve patients with advanced renal cell carcinoma (RCC), according to findings from the phase III JAVELIN Renal 101 study.
Certain Risk Factors Affect Chemo-Related Functional Decline in Elderly Women
September 18th 2018Women aged 65 and older undergoing chemotherapy for breast cancer have a higher risk of experiencing a decline in their ability to function physically, according to a new study published in the Journal of the American Geriatrics Society.
Multidisciplinary Approach to Adverse Event Management Imperative in GU Cancers
September 18th 2018While revisions to guidelines have given clinicians a better handle on how to manage immune-related adverse events (AEs), they have not eliminated the need for individualized treatment of patients with genitourinary (GU) cancers, says Xiao X. Wei, MD, MAS.
CURE Magazine Hosts #CureConnect Tweet Chat on Women's Cancers
September 14th 2018CURE Media Group’s flagship product, CURE® magazine, the nation’s leading consumer digital and print media enterprise focused on patients with cancer, will host its monthly Tweet Chat on Thursday, September 27, at 1 p.m. EDT, for readers to ask questions and to facilitate discussions about women’s cancers.
FDA Approves Moxetumomab Pasudotox for Hairy Cell Leukemia
September 14th 2018The FDA has approved the CD22-directed recombinant immunotoxin moxetumomab pasudotox (Lumoxiti) for the treatment of adult patients with relapsed or refractory hairy cell leukemia (HCL) who have received at least 2 prior lines of therapy, including treatment with a purine nucleoside analog.
Structured Bedside Handoffs Benefit Patients, Nursing Staff
September 12th 2018A study evaluating the implementation of a multifaceted approach to bedside handoffs incorporating the teach-back method and discharge bundles on an inpatient oncology unit at a large military treatment facility showed that patient education reduced patient readmission rate.
FDA Grants Priority Review to Pembrolizumab for PD-L1-High Subgroup of NSCLC
September 12th 2018The Food and Drug Administration (FDA) granted priority review to pembrolizumab (Keytruda) monotherapy for the first-line treatment of patients with locally advanced or metastatic nonsquamous or squamous non-small cell lung cancer (NSCLC) whose tumors express PD-L1 without EGFR or ALK genomic tumor aberrations.