Expert Weighs In On The Future of PARP Inhibitors

Video

Advanced ovarian cancer is deadly for female patients with the disease, but results from a new study show promise for a new frontline treatment.

Patients with advanced ovarian cancer have a higher likelihood of recurrence: over 80% recur after their first-line platinum treatment, according to Bhavana Pothuri, MD, gynecologic oncologist at the NYU Langone Medical Center Perlmutter Cancer Center. One of the reasons for this high rate of recurrence is treatments in the frontline not being effective right away, but that could now change with the addition of PARP inhibitors like niraparib (Zejula).

At the European Society of Medical Oncology 2019 Congress, OncLive®, a sister publication of Oncology Nursing News® , had the chance to interview Pothuri on the implications of the PRIMA study, presented at the conference. She highlighted the effectiveness of niraparib and where the future of PARP inhibitors could go from here.

TRANSCRIPTION

We still need to think about all the data carefully, determine whether HRD testing is indicated in the upfront setting, whether patients who have BRCA-positive tumors or HRD-positive tumors should be prioritized to receive the PARP inhibitor in the frontline setting and perhaps thinking about different strategies in terms of utilizing maintenance in the biomarker-negative group.

Newsletter

Stay up to date on recent advances in oncology nursing and patient care.

Recent Videos
Photo of a woman with brown hair and a floral blouse
Photo of a woman with a blue border around the image
2 experts are featured in this series.
2 experts are featured in this series.
Image of a woman with gray hair and glasses in front of a blue Oncology Nursing News background
Photo of a woman with blond wavy hair wearing a blazer in front of a blue Oncology Nursing News background
Photo of a woman with shoulder-length blond hair in front of an Oncology Nursing News backdrop
Image of a woman with white hair in front of an Oncology Nursing News blue background
2 experts are featured in this series.
Image of a man in a suit standing in front of a blue Oncology Nursing News backdrop