The Impact of Cardiotoxicity Risks in CML: Navigating Dietary Guidelines with TKIs
April 17th 2025Panelists discuss how cardiovascular toxicity remains a significant concern with certain tyrosine kinase inhibitors (TKIs) used in chronic myeloid leukemia (CML) treatment, particularly with the older nilotinib formulation that showed increased cardiotoxicity in long-term trials, though it remains unclear whether this was directly related to poor adherence to fasting guidelines or inherent to the medication's pharmacological properties.
Addressing the Unmet Need in CML Treatment for Patient Treatment Adherence
April 17th 2025Panelists discuss how eliminating the strict mealtime restrictions with the new nilotinib formulation addresses a significant unmet need in chronic myeloid leukemia (CML) treatment by reducing disruption to patients' daily lives, potentially improving medication adherence and overall quality of life for patients who otherwise face a normal life expectancy when their condition is properly controlled.
Understanding the Significance of Nilotinib's New Formulation
April 10th 2025Panelists discuss how the new FDA-approved formulation of nilotinib offers significant advantages over the original version by eliminating fasting requirements, potentially improving patient adherence while maintaining efficacy and reducing the risk of toxicity-related complications such as glucose metabolism issues, elevated cholesterol, and pancreatitis.
How Has the CML Treatment Landscape Evolved Over the Past 5 Years?
April 10th 2025Panelists discuss how chronic myeloid leukemia (CML) treatment has evolved over the past 5 years, highlighting advancements in tyrosine kinase inhibitor (TKI) therapy, improved adverse effect management, tailored treatment approaches through molecular monitoring, and increased emphasis on shared decision-making with patients.
Managing Early HER2+ mBC: Patient-Centered Approaches and Evolving Treatment Strategies
Experts discuss how, it is crucial to approach treatment strategies with both compassion and transparency. It is important to explain the complexity of the situation and maintain clear and accessible language when discussing treatment strategies with patients and their families.
Experts discuss how, there is a role for SRS in treating brain metastases such as if a patient were to have a large singular brain metastasis that is causing symptoms such as seizures of neurological decline, that SRS could be a warranted treatment.
Evolving Treatment Strategies in Early HER2+ Breast Cancer
Experts discuss how, nearly half of patients diagnoses with HER-2 positive metastatic brain cancer do develop brain metastasis. It is thought that larger molecule treatments such as the monoclonal antibodies likely do not cross an intact blood brain barrier which is often why patients develop brain metastases
Bridging Communication Gaps: Comprehensive Care for Upper GI Cancer Treatment
Experts discuss how to facilitate open communication among the patient, caregivers, and the multidisciplinary team to ensure comprehensive care and alignment on treatment goals.
Multidisciplinary Collaboration in Managing Treatment-Related AEs in Upper GI Cancer
Experts discuss how they collaborate with oncologists, nutritionists, and other specialists to manage complex cases involving advanced disease and treatment-related adverse effects (AEs) and the role of the multidisciplinary team in addressing specific patient needs, such as nutritional deficits, pain management, or psychosocial challenges.