Epcoritamab Obtains Accelerated Approval for Relapsed/Refractory DLBCL
May 19th 2023The FDA has granted epcoritamab accelerated approval for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma. The prescribing label comes with boxed warnings for cytokine release syndrome and neurologic problems.
Addition of Cabozantinib to Nivolumab/Ipilimumab Boosts PFS, But also AEs, in Advanced RCC
May 19th 2023Cabozantinib, in combination with nivolumab and ipilimumab, improved progression-free survival in patients with advanced renal cell carcinoma, but the rate of grade 3/4 adverse events was 79%.
Encorafenib/Cetuximab/Binimetinib Triplet Safe and Effective in BRAF V600E–Mutant mCRC
May 16th 2023Treatment with encorafenib in combination with cetuximab and binimetinib was active with a manageable safety profile in the first-line setting for patients with BRAF V600E–mutated metastatic colorectal cancer.
Aumolertinib Plus SRT Achieves Intracranial Responses in Oligometastatic EGFR+ NSCLC
May 10th 2023Prospective phase 2 data demonstrated that aumolertinib, followed by salvage stereotactic radiation therapy, elicited responses in patients with intracranial oligometastatic EGFR-mutant non–small cell lung cancer.