Precision Medicine Highlights the Importance of Biomarkers in Melanoma
December 4th 2020With the identification of actionable alterations, precision medicine continues to lead the way in all areas of oncology, but especially in melanoma, according to Jason J. Luke, MD, FACP, who added that, in order to successfully apply personalized therapy, it’s critical to be fluent in the differences between biomarkers.
Lung Cancer Advancements Continue, Despite COVID-19
December 3rd 2020The coronavirus disease 2019 (COVID-19) pandemic has become another potential complication for patients with lung cancer, said Mark G. Kris, MD, who added that although the pandemic has disrupted patient care, it has yet to stunt scientific collaboration.
FDA Approves Pralsetinib for RET-Altered Thyroid Cancers
December 2nd 2020The FDA approved pralsetinib (Gavreto) for adults and children aged 12 or older with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who need systemic therapy or RET fusion-positive thyroid cancer who require systemic therapy and are radioactive iodine-refractory.
FDA Approves PSMA-Targeted Imaging Drug for Prostate Cancer
December 1st 2020The FDA approved Gallium 68 PSMA-11 (Ga 68 PSMA-11), a drug for PET imaging of prostate-specific membrane antigen (PSMA) positive levels in men with suspected prostate cancer metastasis, who may be curable by surgery or radiation therapy.
CAR T-Cell Therapy Improves Blood Cancer, But Toxicities Are Still Concerning
November 29th 2020Following the approvals of tisagenlecleucel (tisa-cel; Kymriah) and axicabtagene ciloleucel (axi-cel; Yescarta), several research efforts have been dedicated to the development and exploration of CAR T-cell therapies in the realm of leukemias and lymphomas, according to Olalekan O. Oluwole, MBBS, MD, who added that although this modality has moved the needle forward, this approach is not without toxicity.
3D Printing May Improve Reconstruction, Limb Salvage in Bone Tumors, Sarcoma
November 29th 2020The advent of 3D printing has led to an exciting revolution in limb salvage surgery for patients with bone tumors and soft tissue sarcomas, and have resulted in more precise resection and high-fidelity reconstruction, according to R. Lor Randall, MD, FACS.
FDA Approves Naxitamab-gqgk for Pediatric and Adult High-Risk Neuroblastoma
November 26th 2020The FDA has granted an accelerated approval to naxitamab-gqgk (Danyelza) for use in combination with granulocyte-macrophage colony-stimulating factor as a treatment for pediatric patients 1 year of age and older and adult patients with relapsed/refractory high-risk neuroblastoma in the bone or bone marrow who have demonstrated a partial response, minor response, or stable disease to prior treatment.
Tebentafusp Boosts Survival in Metastatic Uveal Melanoma
November 25th 2020Tebentafusp (IMCgp100) showed superiority in overall survival (OS) compared with investigator’s choice of therapy in patients with previously untreated metastatic uveal melanoma, according to results of a preplanned interim analysis of the phase 3 IMCgp100-202 trial (NCT03070392).
The Year of the Nurse and Midwife: Nurses Share Their Thoughts, Feelings on 2020
November 24th 2020To understand the impact of the pandemic, I asked clinical nurses to describe the 2020 The Year of the Nurse and Midwife in a few words. Everyone was eager to give a statement and many, many were very prideful for the nursing care done in 2020.
JAK Inhibitors Build Momentum in Myelofibrosis Treatment
November 24th 2020With additional JAK inhibitors under exploration in the myelofibrosis pipeline, such as momelotinib and pacritinib, FDA-approved options continue to be utilized heavily in the paradigm, explained John O. Mascarenhas, MD.
Asian Patients With HR+, HER2- Breast Cancer Have Higher Recurrence Risk
November 23rd 2020Patients from Asian countries with hormone receptor (HR)–positive, HER2-negative breast cancer may have a higher risk of disease recurrence than those from non-Asian countries, suggesting that this population may benefit from additional adjuvant treatment with abemaciclib (Verzenio).