PARP Inhibitor Improves PFS in Pancreatic Cancer Subset
June 3rd 2019Maintenance therapy with olaparib (Lynparza) significantly improved progression-free survival (PFS) compared with placebo among patients with germline BRCA-mutated metastatic pancreatic cancer, according to results from the phase III POLO trial presented at the 2019 ASCO Annual Meeting.
Heated Chemo During Resection Shows No Benefit in Advanced CRC
July 13th 2018The addition of heated chemotherapy delivered to the abdomen during surgery delivered no survival benefit to patients with peritoneal carcinomatosis, according to phase III study results presented at the 2018 ASCO Annual Meeting.
Trial Induces 'Best Ever' Survival Data Among Young Patients with Certain T-Cell Cancers
July 10th 2018Adding nelarabine to escalating-dose methotrexate increased the 4-year disease-free survival rate to 91% in pediatric and young adult patients with newly diagnosed T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma, according to results from the phase III AALL0434 trial.
Four-Drug Chemo Combo Significantly Improves Pancreatic Cancer Survival
July 9th 2018In a major advance that set a new standard of care for the treatment of patients with resected pancreatic cancer, a modified FOLFIRINOX regimen (mFOLFIRINOX) dramatically improved survival compared with standard gemcitabine as postoperative therapy.
Kidney Removal May Be Unnecessary with Sunitinib Therapy in Metastatic Kidney Cancer
July 6th 2018Sunitinib (monotherapy appeared noninferior to cytoreductive nephrectomy and adjuvant sunitinib, the current standard of care for patients with synchronous metastatic renal cell carcinoma, according to results from a phase III study presented at the 2018 ASCO Annual Meeting.
Liso-Cel Shows Promise in High-Risk Diffuse Large B-Cell Lymphoma
June 7th 2018A promising CD19-directed chimeric antigen (CAR) T-cell therapy, Lisocabtagene maraleucel (JCAR017; liso-cel), may result in durable remissions among patients with high-risk diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma.
Mobile Monitoring Technology Helps to Reduce Symptom Severity in HNC
June 4th 2018Patients with head and neck cancer (HNC) who tracked their symptoms using the CYCORE (CYberinfrastructure for COmparative Effectiveness REsearch) system’s mobile and sensor technology experienced reduced symptom severity compared with those who received standard care, according to results of a large randomized trial.
Relieving Nausea With Olanzapine in Patients Treated for Head and Neck Cancer
June 18th 2015Nausea and vomiting associated with anticancer therapies continue to be among patients' most troubling symptoms. Findings of a clinical trial found that olanzapine demonstrated comparative benefits in relieving these symptoms.